Pathogenesis and treatment of bronchopulmonary dysplasia
نویسندگان
چکیده
منابع مشابه
Pathogenesis of bronchopulmonary dysplasia.
Bronchopulmonary dysplasia (BPD) refers to a heterogeneous group of lung disorders in infants that is commonly associated with prematurity and surfactant deficiency. BPD results from the complex interplay between impairments in the premature lung such as surfactant deficiency, perinatal insults such as infection, and damage resulting from supportive care of the infant due to barotrauma or volut...
متن کاملBronchopulmonary dysplasia: early diagnosis, prophylaxis, and treatment.
ary dysplasia.2 The incidence of bronchopulmonary dysplasia among ventilated infants varies, depending on gestational age, from 4-2% to as high as 40%,'1 4 but increases up to 70% among infants in whom it is necessary to prolong mechanical ventilation beyond two weeks.5 Such infants have an increased mortality and morbidity even after discharge from neonatal intensive care. Readmission is commo...
متن کاملPathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development
Bronchopulmonary dysplasia is a chronic lung disease of preterm infants. It is caused by the disturbance of physiologic lung development mainly in the saccular stage with lifelong restrictions of pulmonary function and an increased risk of abnormal somatic and psychomotor development. The contributors to this disease's entity are multifactorial with pre- and postnatal origin. Central to the pat...
متن کاملLung vascular development: implications for the pathogenesis of bronchopulmonary dysplasia.
Past studies have primarily focused on how altered lung vascular growth and development contribute to pulmonary hypertension. Recently, basic studies of vascular growth have led to novel insights into mechanisms underlying development of the normal pulmonary circulation and the essential relationship of vascular growth to lung alveolar development. These observations have led to new concepts un...
متن کاملmiR34a: a master regulator in the pathogenesis of bronchopulmonary dysplasia
Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants with lifelong pulmonary and neurodevelopmental consequences. The pathogenesis of BPD is contributed by genetic and environmental factors; among the latter, a critical contributor is exposure of the developing lung to hyperoxia. We have recently reported (Nat Comm 8:1173) that hyperoxia exposure in our in vitro a...
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ژورنال
عنوان ژورنال: Current Opinion in Pediatrics
سال: 2011
ISSN: 1040-8703
DOI: 10.1097/mop.0b013e328346577f